Overall, when we go back to Mystic, we will go back to the Hampton Inn.
First, the room was noticeably clean to the point where my 6 year old mentioned it. No dust or debris on tile, sheets were crisp, no dust on flat surfaces and well vacuumed carpets. We started on the 1st floor and asked for a 3rd floor room which was provided no question.
Second, the hotel was convenient to the aquarium first, historic Mystic second (~1 mile) and downtown last (~2 miles). initially hoped to walk to aquarium but that is really viable with kids as you are walking under Interstate 95.
Lastly, the staff did help us whenever we had a question from restaurants, locations and for a roll-away bed. The pull out couch in the suite is really not big enough for two boys (10, 6) but this request was made the evening we checked in and it was in the room within 15 minutes.