Located in the Tennessee River valley nestled between the Cumberland Mountains to the northwest and the Great Smokies to the southeast, Knoxville is buffered from the extreme cold winter temperatures of the north and unbearable hot summer temperatures of the south. Temperatures are most pleasant in Knoxville in the spring and autumn. In addition, visitors to the city in the fall can enjoy the changing colors of the leaves in the forests within and near to the city.

Average temperatures range in the mid-20s in winter and peak in the upper 80s during the summer. The average annual precipitation nears 50 inches; most occurs as rain in the spring and autumn, as the area receives less than 10 inches of snow on average during the winter.