From Albufeira take the highway E1 towards Lisbon however to avoid traffic do not enter Lisbon instead about 50 Kilometres before reaching Lisbon join the A13 direction Santarém than merge with A1 highway that will take you all the way to Coimbra. Without rushing 5 hours should be enough without major stops.
Highways are good and easy to get around. Enjoy it
...and in case you don't have a car, you can either go by train:
or by bus:
From Albufeira to Coimbra it will be, more or less 4 hours... and it is quite easy to reach.
You may take one of the several highways to Lisbon, where you can stop and visit one or two nice spots...then you may take A1 towards Coimbra.
Enjoy your trip and have fun in Coimbra!
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