Can you walk to the campus, if so how far to the central part of campus?
It would be a long walk along busy highway (Virginia Avenue). I don't recall seeing sidewalks along part of Virginia. It is a short drive to campus though, so an intrepid person could probably walk. We got lucky and found parking spots near where we wanted to be. The Hotel is nice and clean. We were only there overnight and were only back and forth to campus twice. So we might have missed some walking route. It would have to be about a mile from center of campus. You might call the hotel and ask them.
Get an answer from Holiday Inn Express Hotel & Suites Lexington- Downtown / University staff and past guests.