Welcome to the best hotel in Beaufort, SC! You'll discover Southern hospitality and charm at the new Holiday Inn Hotel Beaufort, nestled in the heart of South Carolina's Lowcountry. Our location is just off Highway 170 and Route 21 and overlooks the Beaufort River in Beaufort, SC, an antebellum seaside town surrounded by history and beauty. Our hotel in Beaufort, SC welcomes the family and friends attending the year-round graduation ceremonies at the Parris Island Marine Recruitment Center, six miles from our hotel. Beaufort's downtown is rich in history and just one mile away. Enjoy a relaxing and educational horse-drawn buggy tour to discover the secrets of historic Beaufort. And it's easy to spend a day on the inter-coastal waterways of Seabrook Island or Hilton Head Island, as both are just a half-hour away. The Holiday Inn Beaufort is designed to meet the needs of corporate, government, groups and leisure travelers. We are centrally located to Beaufort s business district, two miles from the University of South Carolina at Beaufort and just minutes from Beaufort Memorial Hospital. Our guests can relax around our indoor heated pool & whirlpool or enjoy a workout in the fitness center. A 24-hour business center allows you to catch up on work or check your email. The Holiday Inn Hotel Beaufort welcomes you with top-notch service and true Southern hospitality.