Operating since 1914 and considered one of the wonders of the world, this fifty-mile waterway transports ships by raising them from sea level to more than 85 feet via a series of gravity-powered locks.

This charming old community’s churches, pedestrian walkways and historical plazas and palaces make it a must-see on any tour.

Located at the southern entrance of the Panama Canal and stretching nearly three kilometers into the Pacific Ocean, this popular causeway features many tourist-related venues and activities including hotels, restaurants, and jogging and biking trails.

Located in the middle of Lake Gatun, this island is a unique and fun-filled destination that lets you get up close and personal with monkeys. These curious creatures will come right up to your boat and even jump on board in hopes of a bite of fruit. Monkey Island can only be accessed through a tour (usually from Panama City), which can be combined with a visit to the sloth sanctuary or a rainforest walk. The best time to visit is during the dry season (December to April) when the weather is clear and the monkeys are the most active. – Tripadvisor

Designed by world-renowned architect Frank Gehry, the Biomuseo is his only work in Latin America and the tropics. The building was designed to tell the story of how the isthmus of Panama rose from the sea, uniting two continents, separating a vast ocean in two, and changing the planet's biodiversity forever.

After Lake Mead, this is the world's largest man-made lake that forms the central part of the Panama Canal.