Spread along both sides of the majestic St. John River, Fredericton combines the coziness of a small town with the world-class institutions of a city much larger than this humble capital. Tree-lined streets and suburban neighborhoods of Victorian-era homes live harmoniously alongside three universities, countless historic sites, museums, riverfront trails and restaurants featuring local and international cuisines. Fredericton also boasts a number of world-renowned festivals.

Montreal, c’est si bon! This French-speaking city is considered the cultural capital of Canada, and is a cosmopolitan celebration of Québécois style. A horse-drawn carriage ride around the cobblestone streets and grand buildings of Vieux-Montréal will give you a taste of European flavour. The Basilique Notre-Dame is a confection of stained glass, and the Plateau Mont-Royal district will delight you with its quaint boutiques and cafés. Dig in to a massive plate of poutine to fuel up for a tour of the epic Olympic Park.

Ottawa is a compact, clean, cleverly planned centre of culture and politics. And it's an ideal choice for a weekend getaway. Start downtown at the architecturally stunning National Gallery of Canada, and don't miss the Canadian Nature Museum and the National Aviation Museum. Rideau Canal offers boating in the summer and ice-skating in the winter. Gatineau Park attracts cyclists and walkers, while Byward Market blends old and new Ottawa.

We won't lie: Niagara Falls is uber-touristy. There are wax museums and a Ripley's Believe It or Not Museum, and if it's a fast-food chain, you can probably find it here. But even the most jaded hipster shouldn't pass up a chance to visit this town, because the Falls themselves are spectacular.

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theatre, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.

Toronto's neighbour Mississauga has more than 480 parks and woodlands for you to explore. Stroll the Waterfront Trail, rent a boat at the marina or spend a day at the racetrack. It's also called Ontario's shopping capital, with everything from shopping centres and outlet malls to picturesque village-style shopping streets.

Once a thriving steel town, Youngstown suffered an economic decline immortalized in song by Bruce Springsteen. However, the innovative city has made a comeback, spawning a surge in industry, from software to food to the arts. Dozens of galleries, museums, performance venues and historic sites celebrate the culture of the area. Miles of hiking trails and green spaces offer energetic activities to active travelers. Sports are also highly valued, Youngstown being home to a host of pro athletes.