THE BEST Romantic Bed and Breakfast in Cap-d'Agde

Surrounded by golden sands, oyster-filled lagoons, and ancient salt flats, the Mediterranean port town of Sete offers a tranquil change of pace from the busy resorts of the Languedoc. Effortlessly photogenic, the picturesque canals are lined with fishing boats, traditional markets, and seafood restaurants.

Boasting Medieval fortresses, Roman aqueducts, Mediterranean coastline, endless vineyards and expansive national parks, a visitor could spend a lifetime exploring sunny Languedoc-Rousillon. Sitting on the geographic divide between the Iberian peninsula and mainland Europe, the regions towns and cities, including beautiful Carcassonne, Nimes and Montpellier, are connected by paths both ancient and new. Hike Via Domitia, a Roman road, or rent a barge for a trip down the Canal du Midi.

Getting sick on holiday is a major drag, but if you have to be under the weather, Montpellier is an ideal place to do it. People have studied medicine here for centuries—the Moors established medical schools in the 9th century, and the Université Montpellier’s school of medicine was founded in 1220. Once the local docs give you a clean bill of health, explore the cathedral, mansions and opera house.

"Aigues-Mortes" translates to "dead waters," but the salt marshes surrounding this mediaeval city actually have given this town one of its chief industries: sea-salt production. (Bring some home for epicurean friends.) Fortified into a Mediterranean port in the 12th century, Aigues-Mortes’ massive walls survive—walk along them for great views.

Within easy reach of both the Mediterranean and the Spanish borders, Perpignan blurs the line between French and Catalan cultures. The meandering, palm-dotted Old Town is anchored by a rust-coloured, Romanesque palace—a relic from when the city ruled the Kingdom of Mallorca.

Step back several centuries and imagine yourself in medieval times. Designated a UNESCO World Heritage Site, La Cite at Carcassonne is a painstakingly restored medieval walled city on a hill by the Aude River. You'll half-expect to see armed lookouts manning the fortified city's towers. Cross the river to La Bastide neighbourhood for all the charms of a French country town.

Ottawa is a compact, clean, cleverly planned centre of culture and politics. And it's an ideal choice for a weekend getaway. Start downtown at the architecturally stunning National Gallery of Canada, and don't miss the Canadian Nature Museum and the National Aviation Museum. Rideau Canal offers boating in the summer and ice-skating in the winter. Gatineau Park attracts cyclists and walkers, while Byward Market blends old and new Ottawa.

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theatre, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.

We won't lie: Niagara Falls is uber-touristy. There are wax museums and a Ripley's Believe It or Not Museum, and if it's a fast-food chain, you can probably find it here. But even the most jaded hipster shouldn't pass up a chance to visit this town, because the Falls themselves are spectacular.

Collingwood is more than just a neighbour of Blue Mountain Ski resort. This town on Nottawasaga Bay has its own delights to discover, from historic homes to parks and trails, a marine heritage museum, and its own annual Elvis Festival.

A vacation in Thunder Bay is about immersing yourself in natural splendor. Lake Superior, Sleeping Giant Provincial Park, and all manner of outdoor sports are at your disposal here. Fort William Historical Park’s costumed interpreters bring the region’s history to life for kids.