Boasting two of the nation's best beaches, Saint Petersburg has stunning sands, perfect whether you choose to soak up sun at Fort De Soto; swim, shell, fish or snorkel on Caladesi Island; or enjoy Clearwater's Pier 60 and unbeatable sunsets. Busch Gardens, Adventure Island and eight aquariums and zoos are nearby.

Let the Gulf Shore breeze carry you to a weekend of sun-kissed fun. The Tampa-St Pete area is Florida's second-biggest metropolitan area. Not as flashy as Miami or as crowded as Orlando, the region has grown as a tourist destination, and it's easy to see why: miles of waterfront, sandy beaches, cultural attractions and exciting amusements. Busch Gardens has been drawing visitors for years, but the city also has another zoo, an aquarium and several major museums for those who need some time in the shade.

Visitors find the perfect blend of culture and fun in Bradenton. Discover Florida’s Spanish heritage at the De Soto National Memorial, go for a bike tour of the beautiful Robinson Preserve, and explore an authentic fishing village at Cortez. Be sure to visit the South Florida Museum and catch a Pittsburgh Pirates spring training game — and don’t miss vibrant downtown Bradenton, the picturesque Riverwalk, and the working artists’ community at the Village of the Arts.

Florida's Southwest Gulf Coast contains a constellation of enticing coastal gems. Stunning beaches, including Fort Myers Beach, Tigertail Beach and Pensacola Beach, fringe the Gulf, down the I-75 from Tampa to Naples. Sanibel Island's shells attracts thousands. Cape Coral's waters are paradise for fly-fishing. Golfers adore spectacular courses in Marco Island and Naples. Glorious sunny days and deliciously warm turquoise waters beckon in this often overlooked corner of the Sunshine State.

What kind of beachgoer are you? Chances are, you’ll find something in the Sarasota area that appeals to you. Soft sand, fishing piers, shells—you can find it around here. Just don’t go looking for a nude beach—that’s the one thing they don’t have.

The shark tooth capital of the world, Venice, Florida, is known for its spectacular shoreline. Stroll down Venice Avenue with its pink, Italian Renaissance buildings, Mediterranean-style shops and "umbrella-topped" Canary Island date palms.

From the Magic Kingdom to magical spa treatments, Orlando sparkles with the promise of adventure. Spend a day exploring the world-famous Disney theme parks or screaming your head off on a Universal Studios roller coaster. For a less adrenaline-pumping afternoon, enjoy the quiet natural beauty of the Harry P. Leu Gardens or enjoy a seaweed scrub at a luxury day spa. Savor fresh and local ingredients at one of Orlando’s James Beard-nominated restaurants.

Myrtle Beach is a family-friendly beach destination—which means in addition to great beaches, there’s plenty to do when the kids are sick of making sand castles. Amusement parks, water sports and golf courses are nearby. And family-friendly dining and hotels abound.

Tulum is relaxation and romance with an ancient angle. Guests can enjoy modern takes on traditional Mayan massage and spa treatments, or sunbathe on gorgeous Yucatan beaches within site of well-preserved ancient ruins. A rare mix of beach, archeology and village, Tulum is a romantic getaway like no other.

Houston hums with an energy and independent spirit all its own. A leading cultural and culinary destination in the South, the city is home to over 11,000 restaurants featuring cuisine from more than 70 countries. The thriving arts scene includes resident opera, ballet, symphony and theatre companies. The Museum District houses 19 museums, all within walking distance. Be sure to visit Space Centre Houston, where you can visit NASA’s Historic Mission Control at the Johnson Space Centre.

Scottsdale has more spas per capita than any other city in the U.S.—so whether you’re looking for the latest medi-spa technology or a new-agey, bohemian vibe, there’s sure to be something for you. It's a good thing, too—after spending all day touring the beautiful desert, you'll be grateful for some pampering.

Nearly perfect year-round weather and several impeccably designed championship courses have made Phoenix one of the world's top golf destinations. But there's more to this mild-mannered metropolis than pristine greens and tee times. The greater Phoenix area also offers an array of impressive cultural attractions. Visit the internationally renowned Heard Museum for an in-depth look at Native American history or peruse the fine collection at the Phoenix Museum of Art. Enjoy a ballet performance at the ornate Orpheum Theater, or catch a Broadway show at the state-of-the-art Dodge. In addition to golf, the city offers numerous outdoor activities including rock climbing, hot-air ballooning, desert jeep tours and more. Family-friendly attractions, first-rate shopping, dining and entertainment, and spectacular recreational activities make Phoenix a must-see destination.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."