In the sweltering Georgia heat, no place is as cool as Athens. This hip college town is home to the University of Georgia, Pulitzer Prize winning authors and famous rock musicians. Explore the downtown area, where Victorian buildings are filled with an eclectic combination of independent coffee shops, restaurants and boutiques. Named "Live Music Central," Athens' busy music venues are known around the world. Check out The 40 Watt Club, where The B-52s and R.E.M got their start.

This canal-laced city is a far cry from its rowdy, party image of the past. Today, following renovation and renewal, upmarket stores and restaurants have replaced fast-food stands and T-shirt shops. But the city's biggest draws are its stretch of gorgeous beaches, great swimming, nearly year-round sunshine and close-to-ideal climate. For great shopping, dining and nightlife, you can't go wrong at Las Olas Riverfront, a waterfront entertainment centre with top-notch clothing and jewellery shops, bars and free entertainment. The city has a host of family-friendly options, such as Everglades Holiday Park and the Museum of Discovery and Science. With the network of canals and waterways, boats are part of the Lauderdale lifestyle, and tourists can get in on the act by hiring a boat or hailing a water taxi. There's a lot to do here, but make sure and spend some quiet time just soaking up the sun or strolling along the beach at dusk.

A popular spot for getting wowed or soaked amid natural splendor, Niagara Falls attracts curious spectators and adventurous honeymooners from around the world. The splendid main attraction - more than six million feet of water cascading over a rocky crest - sits partially in the United States and partially in Canada. The U.S. side has recently been busy promoting other activities to lure visitors. Venues like the Aquarium of Niagara offer parents fun and engaging alternatives for kids, after or in between visits to the Falls. Outdoor recreation such as hiking, biking, fishing and camping can be found at the Niagara Falls State Park. The storied history of attempts to conquer the majestic Falls is captured at the Daredevil Museum; the Schoellkopf Museum concentrates on the history and geology. There's more to the Falls than, well, the Falls, including a wide array of dining and lodging options, from budget to upscale. This awe-inspiring region makes for an exhilarating and multi-faceted getaway

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theatre, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.

Ottawa is a compact, clean, cleverly planned centre of culture and politics. And it's an ideal choice for a weekend getaway. Start downtown at the architecturally stunning National Gallery of Canada, and don't miss the Canadian Nature Museum and the National Aviation Museum. Rideau Canal offers boating in the summer and ice-skating in the winter. Gatineau Park attracts cyclists and walkers, while Byward Market blends old and new Ottawa.

Montreal, c’est si bon! This French-speaking city is considered the cultural capital of Canada, and is a cosmopolitan celebration of Québécois style. A horse-drawn carriage ride around the cobblestone streets and grand buildings of Vieux-Montréal will give you a taste of European flavour. The Basilique Notre-Dame is a confection of stained glass, and the Plateau Mont-Royal district will delight you with its quaint boutiques and cafés. Dig in to a massive plate of poutine to fuel up for a tour of the epic Olympic Park.

With nine bays and 36 beaches, Huatulco is ideal for anyone who loves the sun. It's not an overdeveloped resort town, but the hotels are comfortable—even luxurious. Ecotourism is gaining in popularity, so take a break from sunbathing and try river rafting or a hike through the jungle.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."