The bustling port city of Castries is St. Lucia's capital. Shoppers flock to the city's dozens of stores and to Castries Market for fruits, vegetables and handicrafts. Sightseers admire murals painted by a local artist inside Cathedral of the Immaculate Conception, and relax in Derek Walcott Square, named for the St. Lucian Nobel-prize-winning poet. Atop Morne Fortune (Hill of Good Luck) - where the French and English battled over control of the island - visitors take in panoramic vistas.

There's more than one way to enjoy the spa experience in St. Lucia. One is to book a treatment at any of the luxury spas or resorts on the island. The other is to visit Sulphur Springs, inside the bowl of an extinct volcano, where you're welcome to try a volcanic mud bath or the 31°C/88°F Roman bath.

Gros Islet, on the northern tip of St. Lucia, is a blossoming destination, at once remote and exciting.  The best way to explore the shoreline may be Island Riders, where riding veterans and beginners alike can trot along on horseback and chat with the locals.  The Jump Up street party, perhaps the most recognised of the town's attractions, is also a must for a taste of Gros Islet's unique blend of food and music.

This Gallic toehold in the Caribbean exudes a distinctly French air, enticingly spiced up by West Indian warmth. Local culture and cuisine combine both influences. The stylish isle is dominated by Mount Pelée, which destroyed the city of St Pierre in 1902. Black sand beaches and rainforests are found in the north, with yet more beautiful sands to the south. Sights include La Pagerie, birthplace of Napoleon's Empress Joséphine, and Diamond Rock, a 600-foot pinnacle that was once registered as a British warship.

There are 32 islands and cays that make up St. Vincent and the Grenadines (SVG). Nine are inhabited, including the mainland St. Vincent and the Grenadines islands: Young Island, Bequia, Mustique, Canouan, Union Island, Mayreau, Petit St Vincent and Palm Island. The stunning Tobago Cays National Marine Park is also located within SVG. This multi-island Caribbean nation offers a combination of rainforest eco-adventures, scuba diving, classic Caribbean powder-white sand beaches, luxury accommodation and yachting or sailing adventures.

Romance and adventure are in the air on this lush West Indian island in the Caribbean, depending on your coast. To the west, you'll find calm waters and good swimming. To the east, there are massive, competition-caliber waves. Wherever you stay, expect turquoise waters, fine soft sand beaches, catamaran cruises and delicious island fare.

The Dominican Republic lies in the same waters as Cuba and Puerto Rico, taking up the eastern two-thirds of the island it shares with Haiti. Offering a lush interior with a mix of caves, Victorian gingerbread houses and the lore of pirates, plus 900 miles of coastline along its brim, island highlights include riding a cable car up Mount Isabel de Torres and basking on stunning Saona Island. Oh, and did we mention the D.R. is family-friendly, has just about perfect weather and is affordable?

Jamaica is a melting pot of African, Asian, European and Middle Eastern cultures. You'll experience this diversity in its strong crafts tradition, performing arts and distinctive dining options, like ackee and saltfish with roast breadfruit. Take your holiday to new heights at famed cliff jumping spot, Negril Cliffs. Jamaica offers long beaches, protected coves, rugged mountains, waterfalls, caves and sunshine and chances to play in the surf, ride horses and swim with dolphins. Jump in!

U.S. citizens still need to jump through a few hoops to visit Cuba, but as visitors from around the world know, this island offers some amazing opportunities for cultural exchange. Havana is a mix of old-world architecture and of-the-moment culture. Head out of the capital city to the small town of Trinidad to see more Spanish colonial architecture. It’s a UNESCO World Heritage Site and a fantastic home base for a visit to the Valley of the Sugar Mills, a pocket of land that formerly served as the centre of Cuba’s sugar industry.

Cuba's top beach destination sits on a 13-mile-long peninsula with powder soft sands lapped by waters of the Kawama Channel. Resort hotels teem along the shore that U.S. celebrities and gangsters, including Capone, discovered in the 1920s. Clubs and bars provide mojitos and merriment, after long days baking on the beach, golfing, diving or deep sea fishing. Rent a scooter or hop aboard an open-air tourist train or bus to see more of this stunning spot. Caves, keys and virgin forest add to the area's allure.

We've heard Toronto described as "New York City run by the Swiss," and it's true—you can find world-class theatre, shopping and restaurants here, but the sidewalks are clean and the people are friendly. The best place to start is literally at the top—the CN Tower, the tallest freestanding structure in the Western Hemisphere.

Ottawa is a compact, clean, cleverly planned centre of culture and politics. And it's an ideal choice for a weekend getaway. Start downtown at the architecturally stunning National Gallery of Canada, and don't miss the Canadian Nature Museum and the National Aviation Museum. Rideau Canal offers boating in the summer and ice-skating in the winter. Gatineau Park attracts cyclists and walkers, while Byward Market blends old and new Ottawa.

Dozens of nightclubs, hundreds of restaurants and some of Mexico's best beaches await you in Puerto Vallarta. The original colonial town still shines through an endless selection of shopping, art galleries, water and land activities, and hotels. Walk the malecon (boardwalk) and just try to take it all in.

You'll find crashing waves off Cabo's Pacific coast and sheltered, calm water on the Sea of Cortez. Given those options, Cabo has built a rare reputation for both excellent outdoor sports (big-game fishing, diving and kayaking, among others) and pure beach relaxation. Of course, there's also great nightlife. Cabo’s resorts, hotels and inns cater to everyone from honeymooners to families to Hollywood stars seeking a weekend getaway.

Is there any possible way Las Vegas could not be on our "best nightlife" list? The only way we could possibly omit it is on a technicality—since you can do pretty much anything 24/7 in Vegas, it might be wrong to call it "nightlife."