We noticed that you're using an unsupported browser. The TripAdvisor website may not display properly.We support the following browsers:
Windows: Internet Explorer, Mozilla Firefox, Google Chrome. Mac: Safari.
View map
Sponsored by:
Clear all
Your Selections
  Free Wifi Budget Breakfast included Pool Mid-range Free Parking Family-friendly Charming Quiet Restaurant Pets Allowed Suites Kitchenette Fitness centre Room Service Business Internet & up & up Air Conditioning Non-Smoking Hotel Business Centre & up Meeting Rooms Independent Hotels Accessible rooms Cheap Hotels $ $$ $$$ $$$$ Drury Inn & Suites Pear Tree Inn Quality Inn Super 8 Holiday Inn Express Comfort Inn Concierge Baymont Inn And Suites Hotels with Military Discounts Drury Plaza Hotel Travelodge Hotels Ltd Trendy Foodie Like a Local Candlewood Suites Hotels with Weekly Rates Hampton Inn Best Western Plus Days Inn EconoLodge Bar/Lounge Motel 6 Beach Goer Hotels with Smoking Rooms Red Lion Hotels Spring Break Hotels Family Holiday Maker Within 25 km Within 50 km Any distance from Sikeston Depot Museum & Gallery
Accommodation
Price per night
Enter dates & see best prices
to
Amenities
More
Amenities
Location
(reset)
Any Distance
from
Traveller Rating
Hotel class
Style
More
Style
Hotel brand
More
Hotel brand
  • Sort by:
  • Traveller Ranked
  • Best Value
  • Lowest Price
  • Distance
TripAdvisor members only.
Login for exclusive access to hotel deals up to 40% off
Login to get best prices
Like saving money? We search up to 200 sites to help you save up to 30%
Holiday Inn Express & Suites Sikeston
HIExpress.com
US$103
View Deal
115 Hospitality Dr, Sikeston, MO 63801-9304
2.2 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Days Inn Sikeston
TripAdvisor
View Deal
1330 S Main St, Sikeston, MO 63801-9359
2.2 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Pear Tree Inn Sikeston
Hotels.com
US$90
View Deal
2602 E Malone Ave, Sikeston, MO 63801-5318
4.9 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Comfort Inn & Suites Sikeston
SAVE US$10
US$88
Priceline
US$78
View Deal
109 Matthews Ln, Sikeston, MO 63801-5319
4.9 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Drury Inn & Suites Sikeston
Booking.com
US$125
View Deal
2608 E Malone Ave, Sikeston, MO 63801-5318
5.0 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Super 8 Sikeston/Miner Area
Booking.com
US$59
View Deal
2609 E Malone Ave, I-55 Exit 67, Sikeston, MO 63801-5317
5.0 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Country Hearth Inn - Sikeston
Hotwire.com
US$44
View Deal
100 Matthews Ln, Sikeston, MO 63801-5320
5.0 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Americas Best Value Inn & Suites Sikeston MO
SAVE US$4
US$71
Expedia.com
US$67
View Deal
220 S Interstate Dr, Sikeston, MO 63801-8642
5.3 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Best Western Plus Sikeston
Expedia.com
US$85
View Deal
120 S Interstate Dr, Sikeston, MO 63801-8641
5.5 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Motel 6 Sikeston
Booking.com
US$60
View Deal
110 S Interstate Dr, I-55 at US-62/East Malone Street, Exit #67, Sikeston, MO 63801-8641
5.5 km from Sikeston Depot Museum & Gallery
  • Free Parking
  • Free Internet
Quality Inn
SAVE US$12
US$63
Hotels.com
US$51
View Deal
102 Drake St, I-57 ex. 10, Charleston, MO 63834-4304
21.4 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Savings alert: 20% below average rate

The price you found is 20% lower than this hotel's average rate of US$64/night.

We analyze rates over a 60 day period, and compare your selection to the average rate of comparable stays to ensure you're getting the best possible deal.

Eagle Inn
Booking.com
US$51
View Deal
2811 E Marshall St, Highway 60 & 62 East, Charleston, MO 63834-9321
24.0 km from Sikeston Depot Museum & Gallery
  • Free Wifi
Super 8 Charleston MO
Booking.com
US$58
View Deal
310 S Story St, Charleston, MO 63834-8118
24.1 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Econo Lodge
Booking.com
US$57
View Deal
913 Outer Rd, US 60 & One Mile Road, Dexter, MO 63841-1092
34.9 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Baymont Inn & Suites Dexter
Booking.com
US$66
View Deal
1608 Highway Business 60 West, US Hwy 60, Exit AD, Dexter, MO 63841
36.1 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Dexter Inn
SAVE US$2
US$60
Travelocity
US$58
View Deal
1807 W Business US Highway 60, Dexter, MO 63841
36.6 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Hickory House Inn
Booking.com
US$55
View Deal
1802 N Outer Rd, Dexter, MO 63841-8799
36.6 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Quality Inn Cairo Mounds
Booking.com
US$64
View Deal
13201 Kessler Rd, I 57 & Rt 3, Cairo, IL 62914-3101
39.3 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
Travelodge Marston
Booking.com
US$44
View Deal
301 Route Ad, Marston, MO 63866
39.6 km from Sikeston Depot Museum & Gallery
  • Free Wifi
  • Free Parking
No photo provided
U.S. Hwy 51, Rt. 2, Cairo, IL 62914
39.7 km from Sikeston Depot Museum & Gallery
    Hunter Lodge
    Booking.com
    US$61
    View Deal
    501 SE Outer Road, Marston, MO 63866
    39.9 km from Sikeston Depot Museum & Gallery
    • Free Parking
    • Restaurant
    Candlewood Suites Cape Girardeau
    CandlewoodSuites
    US$94
    View Deal
    485 S Mount Auburn Rd, Cape Girardeau, MO 63703-4926
    45.9 km from Sikeston Depot Museum & Gallery
    • Free Wifi
    • Free Parking
    Malden Airport Inn
    2989 N Douglass St, Malden, MO 63863-1011
    46.0 km from Sikeston Depot Museum & Gallery
      Hampton Inn Cape Girardeau I-55 East
      Booking.com
      US$93
      View Deal
      207 S Mount Auburn Rd, Cape Girardeau, MO 63703-4912
      47.1 km from Sikeston Depot Museum & Gallery
      • Free Wifi
      • Free Parking
      Savings alert: 11% below average rate

      The price you found is 11% lower than this hotel's average rate of US$104/night.

      We analyze rates over a 60 day period, and compare your selection to the average rate of comparable stays to ensure you're getting the best possible deal.

      Pear Tree Inn Cape Girardeau West
      Booking.com
      US$80
      View Deal
      103 Cape West Pkwy, Cape Girardeau, MO 63701-8418
      47.2 km from Sikeston Depot Museum & Gallery
      • Free Wifi
      • Free Parking
      Drury Inn & Suites Cape Girardeau
      SAVE US$10
      US$115
      DruryHotels.com
      US$105
      View Deal
      3303 Campster Dr, Cape Girardeau, MO 63701-8472
      47.3 km from Sikeston Depot Museum & Gallery
      • Free Wifi
      • Free Parking
      Holiday Inn Express Cape Girardeau
      HIExpress.com
      US$110
      View Deal
      3253 William St, Cape Girardeau, MO 63703-4961
      47.3 km from Sikeston Depot Museum & Gallery
      • Free Wifi
      • Free Parking
      Auburn Place Hotel & Suites
      Booking.com
      US$79
      View Deal
      3265 William St, Cape Girardeau, MO 63703-4961
      47.3 km from Sikeston Depot Museum & Gallery
      • Free Wifi
      • Free Parking
      Savings alert: 13% below average rate

      The price you found is 13% lower than this hotel's average rate of US$91/night.

      We analyze rates over a 60 day period, and compare your selection to the average rate of comparable stays to ensure you're getting the best possible deal.

      Pear Tree Inn Cape Girardeau Near the Medical Center
      Booking.com
      US$80
      View Deal
      3248 William St, Cape Girardeau, MO 63703-4960
      47.5 km from Sikeston Depot Museum & Gallery
      • Free Wifi
      • Free Parking
      Drury Plaza Hotel Cape Girardeau Conference Center
      Booking.com
      US$115
      View Deal
      3351 Percy Dr, Cape Girardeau, MO 63701-4913
      47.8 km from Sikeston Depot Museum & Gallery
      • Free Wifi
      • Breakfast included
      *Prices are the average nightly price provided by our partners and may not include all taxes and fees. Taxes and fees that are shown are estimates only. Please see our partners for more details.