We noticed that you're using an unsupported browser. The TripAdvisor website may not display properly.
We support the following browsers:
Windows: Internet Explorer, Mozilla Firefox, Google Chrome. Mac: Safari.
Want the lowest hotel prices? You're in the right place. We check 200+ sites for you.

Rx Restaurant and Bar

Certificate of Excellence
Map updates are paused. Zoom in to see updated info.
Reset zoom
Updating Map...
Get directions
421 Castle St, Wilmington, NC 28401-5141
+1 910-399-3080
Sun 10:00 - 22:00
Tue - Thu 17:00 - 22:00
Fri - Sat 17:00 - 22:30
More Info
Add Photo Write a Review

196 Reviews from our TripAdvisor Community

Traveller rating
Traveller type
Time of year
Showing 195: English reviews
Wilmington, North Carolina
Level Contributor
16 reviews
13 restaurant reviews
common_n_restaurant_reviews_1bd8 5 helpful votes
5 of 5 bubbles Reviewed 22 August 2016

We came here without reservations just before the crowd. They were nice enough to sit us at a table for two. Appetizers are most unusual, combos of pork and cheese, but very spicy. The entrees were incredible, my wife said she had the best soft shell crab she ever had. I will say I had the best duck legs I... More 

Thank Ronstan
Level Contributor
11 reviews
9 restaurant reviews
5 of 5 bubbles Reviewed 19 August 2016 via mobile

This place is amazing. Delicious food, farm to table. Every penny well spent. Cocktails made with house made ingredients are awesome as well

Thank Josh W
Fiscardo, Greece
Level Contributor
132 reviews
67 restaurant reviews
common_n_restaurant_reviews_1bd8 40 helpful votes
4 of 5 bubbles Reviewed 18 August 2016

Located in an old pharmacy, RX, is sure to delight the locavore. We started with the customary pimento cheese which was delicious but it came with Rx ham which was a total delight. Other standouts for the night were a crispy flounder with warm potato salad and duck with hoppin john. We had eight dishes and each was delicious. Dessert... More 

Thank esemmes
Raleigh, North Carolina
Level Contributor
68 reviews
30 restaurant reviews
common_n_restaurant_reviews_1bd8 20 helpful votes
3 of 5 bubbles Reviewed 15 August 2016

The food at RX was good although a bit overpriced for what you get. There was nothing wrong with the food but for the price, there are several other choices in Wilmington that i would recommend. The service was outstanding however which made up for the meal.

Thank Chip L
Atlantic Beach, NC
Level Contributor
54 reviews
29 restaurant reviews
common_n_restaurant_reviews_1bd8 45 helpful votes
5 of 5 bubbles Reviewed 30 July 2016

After travelling from out of town for a concert that ended up being canceled, we decided to try a new place for dinner (we usually go to well reviewed Indochine). A friend who lives in Wilmington recommended several restaurants in the downtown area, including Rx. We chose it instead of the others because of the menu (changes daily but they... More 

Thank AB28512
wilmington, nc
Level Contributor
51 reviews
42 restaurant reviews
common_n_restaurant_reviews_1bd8 19 helpful votes
5 of 5 bubbles Reviewed 5 July 2016

Great food, simple menu. Have always had great service. A little on the pricey side, but it is well worth it. Have tried the Tile fish, the duck and the steak. All were great with tasty sides. Have also tried the pork belly app and the buffalo pig ears. All I can tell you is don't knock either until you... More 

Thank sailfishnc
Bristol, United Kingdom
Level Contributor
86 reviews
24 restaurant reviews
common_n_restaurant_reviews_1bd8 39 helpful votes
5 of 5 bubbles Reviewed 29 June 2016

Had dinner with family and have to say all very impressed with food. Steak was spot on and other diners also lover theirs. Location is about 15-20 minutes walk from downtown area past (mostly) quite historic looking buildings which was a pleasant walk and gave us an appetite, we got an uber back though.

Thank Mark201105
Level Contributor
5 reviews
common_n_restaurant_reviews_1bd8 3 helpful votes
5 of 5 bubbles Reviewed 25 June 2016 via mobile

We absolutely loved our dinner! From appetizers to dessert! It was the best in Wilmington!! We had a couples date and it was perfect! Although you could bring a family or big crowd in also!

Thank Sonya H
Wilmington, nc
Level Contributor
40 reviews
26 restaurant reviews
common_n_restaurant_reviews_1bd8 15 helpful votes
5 of 5 bubbles Reviewed 24 June 2016 via mobile

Located in an old pharmacy, Rx has all the charm you'd want eating in historic Wilmington. With the menu changing daily you know the food is prepared with fresh ingredients and ideas.

Thank Etorrey766
1 review
5 of 5 bubbles Reviewed 23 June 2016 via mobile

Don't be put off by the neighborhood and unimpressive exterior. This converted pharmacy puts out sophisticated food. We'll worth a visit.

Thank John H

Travellers who viewed Rx Restaurant and Bar also viewed

Wilmington, North Carolina Coast
Wilmington, North Carolina Coast
Wilmington, North Carolina Coast
Wilmington, North Carolina Coast

Been to Rx Restaurant and Bar? Share your experiences!

Write a Review Add Photos & Videos

Is This Your TripAdvisor Listing?

Own or manage this property? Claim your listing for free to respond to reviews, update your profile and much more.

Claim Your Listing
Improve this listing

Restaurant Details

Rating summary
  • Food
    4.5 of 5 bubbles
    4.5 of 5 bubbles
  • Value
    4 of 5 bubbles
    4 of 5 bubbles
Average prices
US$30 - US$30
American, Gluten Free Options
Lunch, Dinner, Brunch, After-hours
Restaurant features
Reservations, Seating, Waitstaff, Serves Alcohol, Full Bar, Wheelchair Accessible
Dining Style
Casual Elegant
Good for
Special Occasion Dining, Child-friendly, Local cuisine, Romantic
Open Hours
10:00 - 22:00
17:00 - 22:00
17:00 - 22:00
17:00 - 22:00
17:00 - 22:30
17:00 - 22:30
Location and Contact Information
  • Address: 421 Castle St, Wilmington, NC 28401-5141
  • Location: United States  >  North Carolina (NC)  >  North Carolina Coast  >  Wilmington
  • Phone Number: +1 910-399-3080
Located in the old Hall's Drugstore on 5th and Castle

Questions & Answers

Here's what previous visitors have asked, with answers from representatives of Rx Restaurant and Bar and other visitors
2 questions
Ask a question
Kingsport, Tennessee, United States
over a year ago
Kingsport, Tennessee, United States
over a year ago

See all questions (2)

Questions? Get answers from Rx Restaurant and Bar staff and past visitors.
Posting guidelines
Typical questions asked:
  • Do you have gluten-free options?
  • Is there a dress code?
  • Do you allow dogs on the outdoor patio?