We are planning a three week trip to Italy in September. We are thinking that we would like to spend 3 to 4 nights in the Tuscany area as others have highly recommended it. Although we will be traveling by train, we thought about renting a car in Siena for the Tuscany area. I am just trying to figure this part of the trip out and would appreciate any suggestions/itineraries/cities to stay in.... We would like to spend some of the time in Siena, Assisi, Orvieto and Montepulciano also. When looking at a map, I guess some of that is in the Umbria area. Another thought would be to rent the car in Siena, see some of Tuscany with the car and then after returning car, take train to Assis and then to Orvieto. Any suggestions greatly appreciated. Thank you.