Provincetown is very different from MV and other places on the Cape.
You can drive or you can take a bus to Hyannis and switch to a bus to Ptown.
If you do not mind driving I would do that so you can stop at other places such as some of the National Seashore sites.
The easiest way to get from Boston to Provicetown would be to take the ferry. It only takes 90 minutes and as long as do not want to stop anywhere else it is the best way.
The Chamber of Commerce motto used to be "Like Nowhere Else."
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