There is an airport in Eugene that handles jets, but to my knowledge there is no public transportation from Eugene to Florence.
There are small airplanes that fly from PDX to Newport, but again as far as I know there is no public transportation from Newport to Florence.
Is there a reason you cannot rent a car?
We are attending a wedding. I'll check PDX to Newport, then see if there is a shuttle there, or rent a car in Newport.
Here's the schedule for Porter Stage Line, but you would have to call them to get some specifics...like where the Eugene pickup spot is. Unless it's at the airport, your connections through Eugene would only become more complicated and expensive, since there is no public transportationn to/from the airport. And connecting by air thru Eugene would run up your tab tremendously.
City2City runs a shuttle from PDX to Eugene and a call to them might reveal whether they know of any service to Florence (or what they might charge to provide one). Their number is 1 (866)999-8001.
As was noted, there is no public transportation between Eugene and Florence. Without a car, you might even have a problem getting around Florence itself.
You'll save yourself a lot of frustration and time by simply renting a car at PDX.
The small plane flights from PDX to Newport are not cheap. You'd be money ahead renting a car. Check the prices for renting in downtown Portland - you can take the MAX train to downtown for about $3 from the airport and then you wouldn't pay airport taxes on a car rental. There are several of the majors with downtown offices.
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