A bit off the interstate into Nebraska City is Arbor Day Lodge, Farm & Orchard. Historic home built by J Sterling Morton who is the founder of Arbor Day! We have not been yet but there is a Lewis & Clark Visitors Center. I think a couple wineries close by as well.
Nebraska City's Arbor Day Lodge
Rockport, MO where you can buy a lot of fireworks that are not legal in Nebraska
Glore Psychiatric Museum in Saint Joseph, MO (a very strange but interesting place with odd old treatments for psychiatric conditions)
Where Jesse James was killed in St. Joseph, MO
I like to stop in St. Joe because it is about a half way point.
There is nothing " Must See" for sure...
If you are taking I-29, Arbor Day lodge is off the path and I would say not worth the detour.
My recommendation - Its only a 3 hour drive, keep the pedal to the metal , you wont even have to stop for gas. .
along the line of the other nebraska city comment I highly recommend the Lewis and Clark visitor's center the first left as you come across the missouri on highway 2
The Pony Express museum is a lot of fun.
Nebraska City is also neat depending on what you are into. It is very 'small town' historic feeling with a lot of things to do.
Also John Browns Cave which is just a few minutes off of I-29 and it was a part of the Underground Railroad. I went when I was a kid and it was interesting but haven't been back.
Just a couple suggestions. :-)
Stop in Weston, MO, just west of St Joes and check out the McCormick Distillary and the wine tasting. Neat little main street area.
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