Nightlife in Southampton?   

Here are a few places:

1) The Bent Brief Pub (has now closed permenantly)

2) The Duke of Wellington Pub, built in 1220, was almost destroyed in 1338 by the French during the Hundred Years’ War.  A century-and-a-half later, the establishment was purchased by a brewer and became a “Bere House,” home to the city’s first brewery.  After Waterloo, it adopted its current name in homage to the country’s current hero.       

3) The Old Farmhouse is even older than the Wellington.  The oldest pub in Southampton, it was built on a farm in 1151.  Over five centuries later, legend has it Oliver Cromwell stayed at the establishment a couple times.  Today it thrives as a drinking hole self-consciously dedicated to the preservation of tradition and rustic environs.

Southampton has extensive non-pub nightlife as well.  There are lounges, modern bars, and music venues, the highlight probably being the aptly-named Leisure World complex—an interlock of clubs, bowling lanes, bars and casino. 

If you prefer smaller, more intimate venues, Bedford Place and London Road could be for you. There are trendy bars like Orange Rooms and Mono and 90 Degrees - all great places to visit without getting too cheesy.  If you want to finish your night off in a club, you only need to stroll around the corner to Junk, Rhino or Whitehouse.