Panama City is a pretty big city, but it is not huge. Though there is a fair share of crime and misdemeanors that every big city will encounter, it is a pretty safe spot to visit. You don't really need to worry about major crime, and you can walk down the streets at night and not have to look over your shoulder. Still, you should always be mindful of your surroundings and make sure you don't wind up in dangerous situations. Don't just take out your wallet and leave it on the table or start counting money out in public. It's always best to try to blend in, and locals don't just open maps and stand around looking confused. You should never just leave your camera slung around you neck, and don't wear shirts sporting the name of the city until after you leave. Panama City experienced a bit of a spurt in crime in the last couple of decades, but in recent years it has dipped again, and the police force has done a good job of countering the problem. If there is any problem, you can just call 911. Also, if you are staying near the beaches, you should keep an eye on your belongings, as there will be lots of tourists and you can easily have your things swiped or accidentally taken.