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Seneca Vacation Rentals

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62 rentals in Seneca.
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7 mi from Clemson, 5000 square ft lake house, beach & deep water, 2 king suites, vacation rental in Seneca

7 mi from Clemson, 5000 square ft lake house, beach & deep water, 2 king suites

4 bedrooms
5 bathrooms
Sleeps 11
Match: Sleeps
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500 feet of PRISTINE WATER FRONTAGE ON BEAUTIFUL LAKE KEOWEE, vacation rental in Seneca

500 feet of PRISTINE WATER FRONTAGE ON BEAUTIFUL LAKE KEOWEE

4 bedrooms
3 bathrooms
Sleeps 10
Match: Sleeps
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Easy access lake front W/  beach, waterfront patio and boat ramp, vacation rental in Seneca

Easy access lake front W/ beach, waterfront patio and boat ramp

6 bedrooms
5 bathrooms
Sleeps 14
Match: Sleeps
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Beautiful Lake Keowee - Super clean home, vacation rental in Seneca

Beautiful Lake Keowee - Super clean home

5 bedrooms
4 bathrooms
Sleeps 18
Match: Sleeps
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Panoramic Views, Best Location on Keowee, 150' of shoreline, 10 min. to Clemson, vacation rental in Seneca

Panoramic Views, Best Location on Keowee, 150' of shoreline, 10 min. to Clemson

2 bedrooms
2 bathrooms
Sleeps 4
Match: Sleeps
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Spectacular lake home with dock and fire pit- room for all - good pets ok-, vacation rental in Seneca

Spectacular lake home with dock and fire pit- room for all - good pets ok-

5 bedrooms
4 bathrooms
Sleeps 13
Match: Sleeps
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NEW LISTING!  Newly Renovated Home with Private Beach and Amenities, vacation rental in Seneca

NEW LISTING! Newly Renovated Home with Private Beach and Amenities

4 bedrooms
4 bathrooms
Sleeps 13
Match: Sleeps
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Paddys Pool Place! Close to Clemson football, Lakes and Mountains!, vacation rental in Seneca

Paddys Pool Place! Close to Clemson football, Lakes and Mountains!

3 bedrooms
4 bathrooms
Sleeps 20
Match: Sleeps
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Clemson Families visit your college kids -avoid hotels Additional 10% discount!, vacation rental in Seneca

Clemson Families visit your college kids -avoid hotels Additional 10% discount!

4 bedrooms
4 bathrooms
Sleeps 11
Match: Sleeps
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Football Weekends Available! 3 miles to CU.  Hartwell Waterfront, Pet friendly!, vacation rental in Seneca

Football Weekends Available! 3 miles to CU. Hartwell Waterfront, Pet friendly!

4 bedrooms
6 bathrooms
Sleeps 10
Match: Sleeps
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Escape to the Lake - Luxury on Lake Keowee for large groups - SUMMER 2021, vacation rental in Seneca

Escape to the Lake - Luxury on Lake Keowee for large groups - SUMMER 2021

9 bedrooms
7 bathrooms
Sleeps 28
Match: Sleeps
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Great Location! Close to town & amenities, just 10 miles from Clemson University, vacation rental in Seneca

Great Location! Close to town & amenities, just 10 miles from Clemson University

4 bedrooms
3 bathrooms
Sleeps 12
Match: Sleeps
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Perfect Lake Hartwell Getaway.  Right On The Water, 12 Minutes From Campus, vacation rental in Seneca

Perfect Lake Hartwell Getaway. Right On The Water, 12 Minutes From Campus

4 bedrooms
4 bathrooms
Sleeps 8
Match: Sleeps
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Clemson/Lake Keowee Vacation Home for Family, Friends and Football Fans!, vacation rental in Seneca

Clemson/Lake Keowee Vacation Home for Family, Friends and Football Fans!

3 bedrooms
3 bathrooms
Sleeps 8
Match: Sleeps
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Deepwater Cove on Beautiful Lake Keowee Complete with Dock and Kayaks, vacation rental in Seneca

Deepwater Cove on Beautiful Lake Keowee Complete with Dock and Kayaks

4 bedrooms
3 bathrooms
Sleeps 14
Match: Sleeps
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Lake Keowee Condo with Great Views! Near Clemson, Hiking and Waterfalls., vacation rental in Seneca

Lake Keowee Condo with Great Views! Near Clemson, Hiking and Waterfalls.

2 bedrooms
3 bathrooms
Sleeps 6
Match: Sleeps
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Fishing Cabin - Keowee 2 bedrooms, 2 bathrooms - Fishing - Kayaking - Porch, vacation rental in Seneca

Fishing Cabin - Keowee 2 bedrooms, 2 bathrooms - Fishing - Kayaking - Porch

2 bedrooms
2 bathrooms
Sleeps 4
Match: Sleeps
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Beautiful 4/3, covered Dock,  2 Lrg.Covered Decks,  4.9 rating, $2400 mon/winter, vacation rental in Seneca

Beautiful 4/3, covered Dock, 2 Lrg.Covered Decks, 4.9 rating, $2400 mon/winter

4 bedrooms
3 bathrooms
Sleeps 11
Match: Sleeps
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Experience our Unique Modern Farmhouse; Quiet cove; 18 Private acres!, vacation rental in Seneca

Experience our Unique Modern Farmhouse; Quiet cove; 18 Private acres!

5 bedrooms
5 bathrooms
Sleeps 18
Match: Sleeps
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20 Minutes to Clemson - Remodeled 4 BR/3 BA Waterfront, vacation rental in Seneca

20 Minutes to Clemson - Remodeled 4 BR/3 BA Waterfront

4 bedrooms
3 bathrooms
Sleeps 10
Match: Sleeps
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Beautiful Log Cabin on Lake Keowee with Dock - Close to Clemson!, vacation rental in Seneca

Beautiful Log Cabin on Lake Keowee with Dock - Close to Clemson!

4 bedrooms
3 bathrooms
Sleeps 10
Match: Sleeps
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LAKEFRONT! Dock available. 4 Bedroom 4 Bath Condo 1.5 Miles from Clemson Stadium, vacation rental in Seneca

LAKEFRONT! Dock available. 4 Bedroom 4 Bath Condo 1.5 Miles from Clemson Stadium

4 bedrooms
4 bathrooms
Sleeps 10
Match: Sleeps
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Tee House on BEAUTIFUL Lake Keowee, vacation rental in Seneca

Tee House on BEAUTIFUL Lake Keowee

4 bedrooms
4 bathrooms
Sleeps 8
Match: Sleeps
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Paradise on Lake Keowee, vacation rental in Seneca

Paradise on Lake Keowee

4 bedrooms
4 bathrooms
Sleeps 7
Match: Sleeps
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Clemson/Lake Hartwell house - big water views, dock, 10 minutes to Clemson, vacation rental in Seneca

Clemson/Lake Hartwell house - big water views, dock, 10 minutes to Clemson

5 bedrooms
3 bathrooms
Sleeps 14
Match: Sleeps
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' Estate on the Lake'! 7 BR/7 BA( 6 Suites)Over 8,400 Square Feet! Private Pool!, vacation rental in Seneca

' Estate on the Lake'! 7 BR/7 BA( 6 Suites)Over 8,400 Square Feet! Private Pool!

7 bedrooms
7 bathrooms
Sleeps 18
Match: Sleeps
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Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson, vacation rental in Seneca

Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson

4 bedrooms
4 bathrooms
Sleeps 15
Match: Sleeps
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Charming Keowee Lakeview Home - Near Clemson, vacation rental in Seneca

Charming Keowee Lakeview Home - Near Clemson

3 bedrooms
3 bathrooms
Sleeps 7
Match: Sleeps
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Beautiful Lake Views at Lake Keowee House, vacation rental in Seneca

Beautiful Lake Views at Lake Keowee House

3 bedrooms
3 bathrooms
Sleeps 8
Match: Sleeps
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Lakefront House Steps Away from Swimming, Boating, Kayaking & Relaxing, vacation rental in Seneca

Lakefront House Steps Away from Swimming, Boating, Kayaking & Relaxing

4 bedrooms
3 bathrooms
Sleeps 11
Match: Sleeps
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Brand new! 4 BR Lakefront Home. Private Dock, Big water views! 15min to Clemson, vacation rental in Seneca

Brand new! 4 BR Lakefront Home. Private Dock, Big water views! 15min to Clemson

4 bedrooms
4 bathrooms
Sleeps 12
Match: Sleeps
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**Beautiful Lake Keowee Home Sleeps 15 ** GET AWAY AND RELAX!!, vacation rental in Seneca

**Beautiful Lake Keowee Home Sleeps 15 ** GET AWAY AND RELAX!!

5 bedrooms
4 bathrooms
Sleeps 15
Match: Sleeps
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Lake Keowee Lakefront Home W/ Private Boat Ramp-Great Rates, vacation rental in Seneca

Lake Keowee Lakefront Home W/ Private Boat Ramp-Great Rates

3 bedrooms
3 bathrooms
Sleeps 10
Match: Sleeps
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Comfortably Designed Lake Keowee Waterfront, Minutes to Clemson- In Seneca, vacation rental in Seneca

Comfortably Designed Lake Keowee Waterfront, Minutes to Clemson- In Seneca

5 bedrooms
4 bathrooms
Sleeps 10
Match: Sleeps
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Beautiful Lakefront Rental on Lake Keowee near Clemson. Pets welcome!, vacation rental in Seneca

Beautiful Lakefront Rental on Lake Keowee near Clemson. Pets welcome!

4 bedrooms
3 bathrooms
Sleeps 16
Match: Sleeps
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THE Premier Clemson /Seneca Lake Home, vacation rental in Seneca

THE Premier Clemson /Seneca Lake Home

4 bedrooms
3 bathrooms
Sleeps 10
Match: Sleeps
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Fall fun at the cabin! Convenient to Lake Keowee and Clemson, vacation rental in Seneca

Fall fun at the cabin! Convenient to Lake Keowee and Clemson

3 bedrooms
2 bathrooms
Sleeps 8
Match: Sleeps
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Clemson Game Ready!  5 Miles To Death Valley On Lake Hartwell. NO CLEANING FEES!, vacation rental in Seneca

Clemson Game Ready! 5 Miles To Death Valley On Lake Hartwell. NO CLEANING FEES!

3 bedrooms
3 bathrooms
Sleeps 6
Match: Sleeps
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Furnished apartment perfect for short term stay!, vacation rental in Seneca

Furnished apartment perfect for short term stay!

1 bedroom
1 bathroom
Sleeps 4
Match: Sleeps
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Lake front home with dock, boat ramp and pool.  Minutes from downtown Clemson., vacation rental in Seneca

Lake front home with dock, boat ramp and pool. Minutes from downtown Clemson.

5 bedrooms
3 bathrooms
Sleeps 18
Match: Sleeps
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Brand new! 4 BR Lakefront Home. Private Dock, Big water views! 15min to Clemson, vacation rental in Seneca

Brand new! 4 BR Lakefront Home. Private Dock, Big water views! 15min to Clemson

4 bedrooms
4 bathrooms
Sleeps 10
Match: Sleeps
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The Cutt, Relaxing, private,  lake front paradise on stunning Lake Keowee in SC., vacation rental in Seneca

The Cutt, Relaxing, private, lake front paradise on stunning Lake Keowee in SC.

4 bedrooms
4 bathrooms
Sleeps 12
Match: Sleeps
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Lake Keowee Waterfront Home 15 miles from Clemson!, vacation rental in Seneca

Lake Keowee Waterfront Home 15 miles from Clemson!

8 bedrooms
5 bathrooms
Sleeps 18
Match: Sleeps
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Lakefront Home with Private Boat Ramp, vacation rental in Seneca

Lakefront Home with Private Boat Ramp

5 bedrooms
5 bathrooms
Sleeps 8
Match: Sleeps
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Private setting close to Clemson University, vacation rental in Seneca

Private setting close to Clemson University

3 bedrooms
2 bathrooms
Sleeps 8
Match: Sleeps
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Seneca Serenity.  The Ultimate Getaway on Lake Keowee!!, vacation rental in Seneca

Seneca Serenity. The Ultimate Getaway on Lake Keowee!!

7 bedrooms
5 bathrooms
Sleeps 24
Match: Sleeps
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Family getaway on lake near Clemson campus., vacation rental in Seneca

Family getaway on lake near Clemson campus.

4 bedrooms
3 bathrooms
Sleeps 12
Match: Sleeps
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Lakefront Keowee Cabin 14 Miles to Clemson w/ Hot Tub, vacation rental in Seneca

Lakefront Keowee Cabin 14 Miles to Clemson w/ Hot Tub

4 bedrooms
4 bathrooms
Sleeps 12
Match: Sleeps
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Lake Keowee lakefront 4 bedroom 3 bath home with dock, patio and fire pit., vacation rental in Seneca

Lake Keowee lakefront 4 bedroom 3 bath home with dock, patio and fire pit.

4 bedrooms
3 bathrooms
Sleeps 10
Match: Sleeps
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*Relaxed Cancelation Policy* Clemson Grads;CHRISTMAS;extended stay Duke Power, vacation rental in Seneca

*Relaxed Cancelation Policy* Clemson Grads;CHRISTMAS;extended stay Duke Power

3 bedrooms
2 bathrooms
Sleeps 6
Match: Sleeps
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